Children’s Health In Utero and Childhood Polybrominated Diphenyl Ether (PBDE) Exposures and Neurodevelopment in the CHAMACOS Study
نویسندگان
چکیده
results: Maternal prenatal PBDE concentrations were associated with impaired attention as mea sured by a continuous performance task at 5 years and maternal report at 5 and 7 years of age, with poorer fine motor coordination—particularly in the nondominant—at both age points, and with decrements in Verbal and FullScale IQ at 7 years. PBDE concentrations in children 7 years of age were significantly or marginally associated with concurrent teacher reports of attention problems and decrements in Processing Speed, Perceptual Reasoning, Verbal Comprehension, and FullScale IQ. These associations were not altered by adjustment for birth weight, gestational age, or maternal thyroid hormone levels.
منابع مشابه
In Utero and Childhood Polybrominated Diphenyl Ether (PBDE) Exposures and Neurodevelopment in the CHAMACOS Study
BACKGROUND California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest worldwide. PBDEs are known endocrine disruptors and neurotoxicants in animals. OBJECTIVE Here we investigate the relation of in utero and child PBDE exposure to neurobehavioral development among participants in CHAMACOS (Center for the Health Assessment of Mothers and Chi...
متن کاملPrenatal and childhood polybrominated diphenyl ether (PBDE) exposure and attention and executive function at 9-12 years of age.
OBJECTIVE California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest measured worldwide. We previously reported associations for prenatal and childhood PBDE exposures with decrements in attention, processing speed, fine motor coordination, and cognition in children at ages 5 and 7 years. Here, we investigate associations of PBDEs with attenti...
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Dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ether (PBDE) flame retardants, and polychlorinated biphenyls (PCBs) are believed to be endocrine-disrupting chemicals (EDCs) in humans and animals. The purpose of this study is to examine the relationship of in utero and childhood exposure to these purported EDCs and reproductive hormones in adolescent boys who participated in CHAMA...
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The largest study to investigate the effects of human exposure to polybrominated diphenyl ether (PBDE) flame retardants reports evidence of impaired neurobehavioral development in connection to both prenatal and childhood exposures [EHP 121(2):257–262; Eskenazi et al.]. Associations were greatest for attention, fine motor coordination, and cognition in school-age children. The study focused on ...
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